ABSTRACT
Infective endocarditis (IE) during pregnancy and subsequent cardiac surgery are rare and associated with a high risk of mortality for the mother and fetus. It is difficult to determine the right time for cardiac intervention when IE is diagnosed early in pregnancy. A 33-year-old previously healthy woman in the 11th week of pregnancy was diagnosed with IE and underwent surgical intervention. The cardiopulmonary bypass settings and the anesthetic drugs were carefully chosen. Although she was in good health, while being discharged, the fetus did not survive. Anesthesiologists prioritizing the mother's survival should aim to improve fetal outcomes in such cases.
ABSTRACT
Objective To explore the incidence and characteristics of thyroid disease in early pregnancy and to provide a scientific basis for eugenics .Methods The chemiluminescence immunoassay was used to detect the concentrations of serum thyrotropin (TSH) ,free thyroxine (FT4) ,triiodothyronine (FT3) and thyroid peroxidase antibody (TPOAb) in 776 early pregnant women (<12+6 weeks ,experiment group) and 100 non‐pregnant child‐bearing women (control group) .The test results were analyzed accord‐ing to the different diagnostic criteria of early pregnancy and non‐pregnant childbearing women .Results The serum concentrations of TSH ,FT4 and TPO‐Ab had statistical differences between the experimental group and the control group (P<0 .05) .The inci‐dence rate of thyroid diseases in early pregnant women was 35 .05% ,which was significantly higher than 15 .00% in non‐pregnant childbearing women ,and the difference was statistically significant (P<0 .05) .The thyroid diseases in pregnant women of the ex‐perimental group were mainly hypothyroidism (9 .28% ) and sub‐clinical hypothyroidism (22 .94% ) ,compared with the control group ,the difference was statistically significant(P<0 .05) .Conclusion Early pregnancy has high incidence rate of thyroid disease , which can lead to birth defects .Therefore ,screening early gestation thyroid diseases should be paid attention to provide theoretical basis for eugenics .
ABSTRACT
Objective The purpose of this study was to evaluate the effect of hemoglobin (Hb) level during early gestation on the cognitive development of children at 4-6 years of age.Methods A total number of 3609 children were randomly selected from all the live birth infants whose mothers participated in a community intervention trial during 1993-1996 in 13 counties or cities in Jiangsu and Zhejiang provinces. Hb concentration during early gestation was measured at first prenatal examination and intelligence quotients (IQ), including full-scale, verbal and performance were assessed using Chinese-Wechsler Intelligence Scale for Children in 2000-2001 when these children had a mean age of 68 months. Results Compared with children whose mothers were non-anemic during early gestation, children whose mothers were anemic had a 0.6 point higher mean verbal scale IQ, a 0.9 point higher mean performance IQ and a 0.8 point higher mean full-scale IQ.These differences were not statistically significant when children' s gender, age at intelligence test,region, parity and mother' s IQ, education level and occupation were adjusted for. When mother-child pairs were divided into 5 sub-groups of every 20 percentiles according to Hb concentration during early gestation, verbal IQ scores of the lowest(Hb＜ 103 g/L), the moderate(110 g/L≤ Hb＜ 116 g/L)and the highest Hb concentration group (Hb≥124 g/L) were 91.6 ± 18.9, 92.8 ± 18.2 and 90.3 ±18.6, respectively. The performance IQ scores were 104.7 ± 15.2, 1 04.5 ± 14.3 and 103.5 ±15.1, and full-scale IQ scores were 97.8 ± 17.3,98.4 ± 16.3 and 96.4 ± 17.4, respectively. After controlling for confounding factors, children whose mothers had highest Hb concentration were 54% (OR= 1.54,95%CI:1.13-2.11)more likely to have poor verbal scores and 53% (OR= 1.53,95%CI: 1.10-2.12)more likely to have poor full-scale scores than children whose mothers had moderate -Hb concentration. No statistical associations were noticed between high -Hb concentration and performance scores, or between low Hb concentration during early gestation and verbal, performance as well as full-scale score of pre-school children. Conclusion High maternal Hb concentration during early gestation might adversely affect children' s cognitive development.